pijus-kanti-behman

Pijus Kanti Barman

Assistant Professor
pijus.barman@mahindrauniversity.edu.in

Monocytes are innate immune cells which are produced in the bone marrow by differentiation of hematopoietic stem and progenitor cells (HSPCs). Monocytes have various functions including anti-microbial defense, tissue repair, and antigen presentation. Our lab studies monocyte development and the role of monocyte subsets during infectious diseases and metabolic stress such as type 2 diabetes and obesity. We are also interested in defining the mechanisms involved in the alteration of bone marrow niche for hematopoietic stem cells (HSCs) during aging and metabolic stress.

B.Sc

  • B.Sc (2003-2006); University of Calcutta, Calcutta, West Bengal, India

M.Sc

  • M.Sc (2006-2008); Guru Nanak Dev University, Amritsar, Punjab, India

Ph.D

  • Ph.D (2009-2016); Institute of Life Sciences, Bhubaneswar, Odisha, India

2019 - 2022

  • Postdoctoral Research Scientist (2019-2022); Cedars-Sinai Medical Center, Los Angeles, California, USA
  • Project Scientist (2022); Cedars-Sinai Medical Center, Los Angeles, California, USA

2016 - 2019

  • Postdoctoral Research Associate (2016-2019); University of Illinois at Chicago, Chicago, Illinois, USA

2022

  • Barman PK,Shin JE, Lewis SA, Kang S, Wu D., Wang Y, Yang X, Nagarkatti PS, Nagarkatti M, Messaoudi I, Benayoun BA, Goodridge HS. Production of MHCII-expressing classical monocytes increases during aging in mice and humans. Aging Cell. 2022 Aug 30; 00:e13701.
  • Barman PK, Goodridge HS. Microbial sensing by hematopoietic stem and progenitor cells. Stem Cells, 2022 Jan 19; 40, 14–21.

2020

  • Barman PK,and Koh TJ. Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes. Front Cell Dev Biol, 2020 Jun 26; 8, 528.

2019

  • Barman PK, Urao N, and Koh TJ. Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing. J Pathol, 2019 Jul 18; 249, 435-446.
  • Wolf AA, Yanez A, Barman PK,and Goodridge HS. The Ontogeny of Monocyte Subsets. Front Immunol, 2019 Jul 17; 10, 1642.
  • Barman PK, Pang J, Urao N, and Koh TJ. Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency. J Immunol, 2019 March 25; 202, 2720-2727. (Featured in “In this issue - Skin Wounding Sparks Monocytes”).

2018

  • Fang MM, Barman PK,Thiruppathi M, Mirza RE, McKinney RD, Deng J, Christman JW, Du X, Fukai T, Ennis WJ, et al. Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage. J Immunol, 2018- Sep 18; 201, 2414-2426.

2016

  • Barman PK,Mukherjee R, Prusty BK, Suklabaidya S, Senapati S, and Ravindran B. Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice. Cell Death Dis, 2016 Jul 4; 7, e2224.

2015

  • Mukherjee R, Barman PK,Thatoi PK, Tripathy R, Das BK, and Ravindran B. (2015). Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous. Sci Rep, 2015 Sep 11; 5, 13886.

2009

  • Mukherjee R, Barman PK,Thatoi PK, Tripathy R, Das BK, and Ravindran B. (2015). Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous. Sci Rep, 2015 Sep 11; 5, 13886.

Book Chapter

2020

  • Barman, P.K., Koh, T.J.Bone marrow monopoiesis and wound healing in diabetes. Academic Press, 2020, 535-553. Wound Healing, Tissue Repair, and Regeneration in Diabetes.

Monocytes and Infectious Diseases

Human and animal communities residing in infectious disease endemic regions can be classified into three categories; (i) “symptomatic carriers”, who develop infections with pathologies and hence are susceptible to the infections, (ii) “asymptomatic carriers”, who are infected but without any pathology and hence are tolerant to the infections and (iii) “uninfected”, who are exposed to the pathogens but are not infected and hence are resistant to the infections. We are interested in studying the role of monocyte subsets in “susceptibility versus resistance versus tolerance” against infectious pathogens using mouse models of infectious diseases and human patients.

Bone Marrow Microenvironment

Hematopoietic stem cells (HSCs) reside in bone marrow niche which contains various components including mesenchymal stromal cells (MSCs) and sympathetic nerves. Increased β2-adrenergic receptor signaling from sympathetic nerves to MSCs is believed to alter HSCs in turn to produce more myeloid cells during aging and metabolic stress. We are interested in defining the mechanisms involved in increased β2-adrenergic receptor signaling in the bone marrow during aging and metabolic stress using mouse models.